BUPIVACAINE HYDROCHLORIDE

Bupivacaine Hydrochloride

Bupivacaine hydrochloride used further in formulations which are used mainly in Parenteral application as long acting local anaesthetics. It works by blocking the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anaesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibres. The Parenteral application Indications as local dental anaesthetic peripheral nerve blocks, caudal anaesthesia, epidural spinal anaesthesia for surgery.

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CHEMISTRYCT
Name of the Product Lidocaine Base
Molecular Structure
Systematic IUPAC Name 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide
hydrochloride monohydrate
CAS Number 6108-05-0
Pharmacopoeia IP/BP/EP/USP
Formula C14H22N2O,HCl,H2O
Molecular Mass 288.8 g/mol
PHYSICAL DATA
Physical state and appearance Solid (Crystalline solid)
Color White
Odour Odourless
Melting Point 1070 to 1080C
Drug Type Approved Drug
Drug Category Anesthetic agent : Local aesthesia, Spinal anesthesia
Dosage Forms Gel, Parenteral (sterile).
Storage Store at controlled room temperature of 15-30°C (59-86°F). Protect from freezing and extreme heat.