Lidocaine Base

Lidocaine Base

Lidocaine Base Solution is used for pain:

Temporarily mouth, throat or nose, digestive tract and to eliminate the pain. Determined by your doctor as it can also be used for other conditions. Lidocaine base Ahmedabad is a local anesthetic. Nerve transmission of pain impulses from the brain by preventing functions.

Lidocaine Base India is used topically to relieve itching, burning and pain of inflamed skin inhibit ion fluxes across membranes, particularly sodium transport across the cell membrane decreases increasing depolarization phase action potential blocking nerve action potential.

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Overview

Back Ground:

Although transdermal preparations of the local anesthetics are used to reduce the pain caused by surgery of the skin, these preparations can not effectively penetrate through the epidermis due to the barrier of the stratum corneum and epidermis thick. Ethosomes can effectively transport drugs across the skin due to their thermodynamic stability, small size, high encapsulation efficiency and the percutaneous penetration. Ethosomes lidocaine was evaluated by the measurement base of the charging efficiency , encapsulation efficiency, thermodynamic stability and the ability of in vitro percutaneous penetration and efficacy and skin irritation in vivo.

METHODS:

Lidocaine base ethosomes were prepared using the injection method – sonication – filter. Efficiency size , charge, encapsulation efficiency , and stability were evaluated using a Zetasizer and high performance liquid chromatography. The formulation is determined by measuring the maximum efficiency of the orthogonal test encapsulation. Percutaneous penetration efficiency was analyzed in vitro experiment using a Franz diffusion cell – type. In vivo efficacy was analyzed by prick test. Skin irritation tests were performed on white guinea pigs , followed by histopathological analysis. The results were compared with liposomes lidocaine and lidocaine delivered hydroelectric solution.

CONCLUSIONS

Ethosomes are potential carriers of local anesthetic through the skin and may have applicability to other percutaneous drugs requiring rapid onset.

Name of the ProductLidocaine Base
Molecular Structure
Systematic IUPAC Name2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide
Identifiers
CAS Number137-58-6
PharmacopoeiaUSP/BP/EP
Chemical Data
FormulaC14H22N2O
Molecular Mass234.34 g/mol
Physical Data
Physical state and appearanceSolid (Crystalline solid)
ColorWhite
OdorCharacteristic
Melting Point66oC to 70oC
Drug TypeApproved Drug
Drug CategoryAntiarrhythmic Agents, Anesthetics
Dosage FormsCream, Gel, Implant, Jelly, Kit6. Liquid, Ointment, Solution, Spray
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 400C (1040F).
(preferably store at temperature between 150C and 300C)